We have current stocks of these natural products for research purposes. They were generated from our microbial collection and can be produced in larger quantities as needed. Please contact Matthew Todd for pricing.
1) Apicidin is a fungal metabolite with potent broad spectrum antiprotozoal activity in vitro and efficacy against Plasmodium berghei malaria in mice. It is a potent HDAC inhibitor originally isolated from fermentations of the microbe Fusarium pallidoroseum (Costa Rica).
2) Ondeyka, J. G.; Helms, G.; Hensens, O. D.; Goetz,M. A.; Zink, D. L; Tsipouras, A.; Shoop, W. L.; Slayton, L.; Dombrowski, A. W.; Polishook, J. D.; Ostlind, D.; Tsou, N.;Ball, R. G.; Singh, S. B. “Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium sp., Isolation, Structure Determination and Chemical Transformations” J. Am. Chem. Soc. 1997, 119, 8809.
3) Meinke, P. T.; Colletti, S. L.; Fisher, M. H.; Wyvratt, M. J.; Shih, T. L.; Ayer, M. B.; Li, C.; Lim, J.; Ok, D.; Salva, S.; Warmke, L. M.; Zakson, M.; Michael, B. F.; deMontigny, P.; Ostlind, D. A.; Fink, D.; Drag, M.; Schmatz, D. M.; Shoop. W. L. “Discovery of the Development Candidate N-tert-Butyl Nodulisporamide: A Safe and EfficaciousOnce Monthly Oral Agent for the Control of Fleas and Ticks on Companion Animals” J. Med. Chem. 2009, 52, 3505–3515.