Natural Products Discovery Institute
Natural Products Discovery Institute

Home of the former Merck and Schering-Plough Natural Products Libraries

A Division of The Baruch S. Blumberg Institute

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Pure Natural Products

We have current stocks of these natural products for research purposes.  They were generated from our microbial collection and can be produced in larger quantities as needed.   Please contact Matthew Todd for pricing.

Name
CAS Number
Bioactivity

folipastatin
139959-71-0
animal growth permittant

nidulin
10089-10-8
animal growth permittant

nornidulin
33403-37-1
animal growth permittant

unguinol
36587-59-4
animal growth permittant

arundifungin
194724-72-6
antifungal

hypoxysordarin
251298-72-3
antifungal

ilicicolin H
12689-26-8
antifungal

sordarin
11076-17-8
antifungal
apicidin1
183506-66-3
HDAC Inhibitor

apicidin C
366448-28-4
HDAC Inhibitor

apicidin D2
177562-78-6
HDAC Inhibitor
cytochalasin B
14930-96-2
antitumor
nodulisporic acid 2,3
163120-03-4
ectoparasiticide

xanthomegnin
1685-91-2
ectoparasiticide
xanthoepocin
307494-35-5
antibacterial

kibdelomycin
1380401-59-1
antibacterial

helvolic acid
29400-42-8
antibacterial

podosporin A
116076-62-1
antifungal
paraherquamide A
77392-58-6
anthelmintic

1) Apicidin is a fungal metabolite with potent broad spectrum antiprotozoal activity in vitro and efficacy against Plasmodium berghei malaria in mice. It is a potent HDAC inhibitor originally isolated from fermentations of the microbe Fusarium pallidoroseum (Costa Rica).

2) Ondeyka, J. G.; Helms, G.; Hensens, O. D.; Goetz,M. A.; Zink, D. L; Tsipouras, A.; Shoop, W. L.; Slayton, L.; Dombrowski, A. W.; Polishook, J. D.; Ostlind, D.; Tsou, N.;Ball, R. G.; Singh, S. B. “Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium sp., Isolation, Structure Determination and Chemical Transformations” J. Am. Chem. Soc. 1997, 119, 8809.

3) Meinke, P. T.; Colletti, S. L.;  Fisher, M. H.; Wyvratt, M. J.; Shih, T. L.; Ayer, M. B.; Li, C.; Lim, J.; Ok, D.; Salva, S.; Warmke, L. M.; Zakson, M.; Michael, B. F.; deMontigny, P.; Ostlind, D. A.; Fink, D.; Drag, M.; Schmatz, D. M.; Shoop. W. L. “Discovery of the Development Candidate N-tert-Butyl Nodulisporamide: A Safe and EfficaciousOnce Monthly Oral Agent for the Control of Fleas and Ticks on Companion Animals” J. Med. Chem. 2009, 52, 3505–3515.

For more information about the NPDI, or how to access the collection, please contact Matthew Todd at matthew.todd@bblumberg.org or 215-301-3575.

Supporting this treasure is now possible through charitable contributions to the Blumberg Institute. One can direct donations towards discovery of natural products in the area of donor's interests.

Or shop at smile.amazon.com and designate Baruch S. Blumberg Institute as your charity of choice and you will be supporting our research.

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Natural Products
Discovery Institute

3805 Old Easton Road
Doylestown, PA 18902

215-301-3575 voice
215-489-4920 fax

Natural Products and Human Health

Penicillin, Taxol, Avermectin and Lovastatin were all derived from plant and microbial extracts. Indeed, even today, half of newly approved medications have come from natural products.
See how you can benefit from natural products.

News from NPDI

  • World Renowned Natural Products Researcher Collaborates with the NPDI
  • Presentation at Natural Product Discovery & Development in the Post Genomic Era, San Diego, CA
  • Virginia Tech Bioscientists Look at Natural Extracts for New Malaria Treatment

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